PF-03814735

Product Name:	PF-03814735
CAT#:	DEERD-2312-LGZ-4
Package:	5mg/10mg/50mg/100mg
Datasheet

Description

PF-03814735 is an inhibitor of Aurora A/B, its IC50 value is 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.

Basic Information

Synonyms:	PF03814735
Application:	Aurora A/B Kinase Inhibitor
CAS Number:	942487-16-3
Formula:	C23H25F3N6O2
Molecular Weight:	474.48
SMILES:	CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F

Target Info

Aurora A:	0.8 nM
Aurora B:	5 nM
FLT1:	10 nM
FAK:	22 nM
TrkA:	30 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

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