GSK 525762A (I-BET-762)

Product Name:	GSK 525762A (I-BET-762)
CAT#:	DEERD-2312-LGZ-5
Package:	5mg/10mg/25mg/50mg/(I-BET-762) 10mM * 1mL in DMSO
Datasheet

Description

GSK-525762A is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family

Basic Information

Synonyms:	GSK-525762A; GSK525762A
Application:	BET Inhibitor
CAS Number:	1260907-17-2
Formula:	C22H22ClN5O2
Molecular Weight:	423.9
SMILES:	CCNC(=O)C[C@H]1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C
*Solubility-In vitro:*	DMSO: 72 mg/mL (169.84 mM) Water: Insoluble Ethanol: Warmed: 36 mg/mL (84.92 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

BET proteins (Cell-free assay):

35 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 23.59 mL 0.1 mM_5 mg: 117.95 mL 0.1 mM_10 mg: 235.9 mL 0.5 mM_1 mg: 4.72 mL 0.5 mM_5 mg: 23.59 mL 0.5 mM_10 mg: 47.18 mL 1 mM_1 mg: 2.36 mL 1 mM_5 mg: 11.8 mL 1 mM_10 mg: 23.59 mL 5 mM_1 mg: 0.47 mL 5 mM_5 mg: 2.36 mL 5 mM_10 mg: 4.72 mL

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