CUDC-101

Product Name:	CUDC-101
CAT#:	DEERD-2312-LGZ-3
Package:	10mg/50mg/100mg/200mg/10mM * 1mL in DMSO
Datasheet

Description

CUDC-101 is a novel compound which inhibits multiple targets, which is used to inhibit HDAC, EGFR and Her2.

Basic Information

Synonyms:	CUDC101
Application:	HDAC Inhibitor
CAS Number:	1012054-59-9
Formula:	C24H26N4O4
Molecular Weight:	434.5
SMILES:	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
*Solubility-In vitro:*	In vitro (25°C): DMSO: 20 mg/mL (46.03 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	15% Captisol: 28 mg/mL

Target Info

EGFR: IC50:	2.4nM
HDAC: IC50:	4.4nM
HDAC1: IC50:	4.5nM
HDAC6: IC50:	5.1nM
HDAC3: IC50:	9.1nM
HDAC5: IC50:	11.4nM
HDAC2: IC50:	12.6nM
HDAC4: IC50:	13.2nM
HER2: IC50:	15.7nM
HDAC10: IC50:	26.1nM
HDAC9: IC50:	67.2nM
HDAC8: IC50:	79.8nM
HDAC7: IC50:	373nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 23.01 mL 0.1 mM_5 mg: 115.07 mL 0.1 mM_10 mg: 230.15 mL 0.5 mM_1 mg: 4.6 mL 0.5 mM_5 mg: 23.01 mL 0.5 mM_10 mg: 46.03 mL 1 mM_1 mg: 2.3 mL 1 mM_5 mg: 11.51 mL 1 mM_10 mg: 23.01 mL 5 mM_1 mg: 0.46 mL 5 mM_5 mg: 2.3 mL 5 mM_10 mg: 4.6 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.