GSK 1210151A (I-BET151)

Product Name:	GSK 1210151A (I-BET151)
CAT#:	DEERD-2312-LGZ-6
Package:	5mg/10mg/25mg/50mg
Datasheet

Description

GSK1210151A is a novel selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4.

Basic Information

Synonyms:	GSK1210151A
Application:	BET Bromodomain Inhibitor
CAS Number:	1300031-49-5
Formula:	C23H21N5O3
Molecular Weight:	415.4
SMILES:	CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[C@H](C)C5=CC=CC=N5)OC
*Solubility-In vitro:*	DMSO: Insoluble Water: Insoluble Ethanol: 27 mg/mL (64.99 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

BRD3 (Cell-free assay):	0.25 μM
BRD2 (Cell-free assay):	0.5 μM
BRD4 (Cell-free assay):	0.79 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 24.07 mL 0.1 mM_5 mg: 120.37 mL 0.1 mM_10 mg: 240.73 mL 0.5 mM_1 mg: 4.81 mL 0.5 mM_5 mg: 24.07 mL 0.5 mM_10 mg: 48.15 mL 1 mM_1 mg: 2.41 mL 1 mM_5 mg: 12.04 mL 1 mM_10 mg: 24.07 mL 5 mM_1 mg: 0.48 mL 5 mM_5 mg: 2.41 mL 5 mM_10 mg: 4.81 mL

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