AZD1208

Product Name:	AZD1208
CAT#:	DEP-2312-LGZ-5
Package:	5mg/10mg/25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

AZD1208 is orally available, small molecule inhibitor of PIM kinases, it has potential antineoplastic activity.

Basic Information

Synonyms:	AZD 1208; AZD-1208
Application:	pan-Pim kinase Inhibitor
CAS Number:	1204144-28-4
Formula:	C21H21N3O2S
Molecular Weight:	379.48
SMILES:	C1C[C@H](CN(C1)C2=C(C=CC=C2/C=C\3/C(=O)NC(=O)S3)C4=CC=CC=C4)N
*Solubility-In vitro:*	DMSO: Warmed: 70 mg/mL (184.45 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

Pim1 (Cell-free assay):	0.4 nM
Pim3 (Cell-free assay):	1.9 nM
Pim2 (Cell-free assay):	5 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 26.35 mL 0.1 mM_5 mg: 131.76 mL 0.1 mM_10 mg: 263.52 mL 0.5 mM_1 mg: 5.27 mL 0.5 mM_5 mg: 26.35 mL 0.5 mM_10 mg: 52.7 mL 1 mM_1 mg: 2.64 mL 1 mM_5 mg: 13.18 mL 1 mM_10 mg: 26.35 mL 5 mM_1 mg: 0.53 mL 5 mM_5 mg: 2.64 mL 5 mM_10 mg: 5.27 mL

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