Pim
Pim kinases are a family of serine/threonine protein kinases that play roles in cell development, immune regulation, and tumorigenesis. Early studies identified an oncogenic role of the Pim-1 family in lymphoma. Pim-2 has only 55% amino acid homology with Pim-1, but it is considered a compensatory protein of Pim-1 because it has a very similar kinase domain. Pim-3 catalyzes histone phosphorylation and autophosphorylation. All three Pim proteins can phosphorylate serine and threonine amino acids and activate similar cellular pathways.
Pim kinase is a key in tumor cell signal transduction. It promotes the occurrence and development of tumors by regulating cell cycle progression, accelerating transcription and translation, and inhibiting apoptosis. Highly efficient and low-toxic Pim kinase inhibitors are expected to become a new strategy for tumor treatment.
For more details about our Pim kinases, please click the links listed below.
- TCS PIM-1 1
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CAT#:
DEP-2312-LGZ-11
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CAS Number:
491871-58-0
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Application:
Pim-1 Kinase Inhibitor
- PIM447 (LGH447)
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CAT#:
DEP-2312-LGZ-12
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CAS Number:
1210608-43-7
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Application:
Pim Inhibitor
- AZD1208 HCl
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CAT#:
DEP-2312-LGZ-13
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CAS Number:
1621866-96-3
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Application:
PIM Kinases Inhibitor
- INCB053914 Phosphate
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CAT#:
DEP-2312-LGZ-19
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CAS Number:
2088852-47-3
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Application:
Pim Inhibitor