Aurora Kinase

Aurora kinase is an important serine/threonine kinase responsible for regulating cell mitosis. The structures and functions of members of the aurora kinase family are highly conserved in different model organisms. Abnormally expressed aurora kinase often causes a large number of abnormalities in cells during mitosis.

In addition, Aurora kinase is also involved in the process of tumor formation. Some small molecules targeting aurora have been found to have significant tumor suppressor effects, and aurora inhibitors have been proven to effectively reduce cancer activity. For proper inhibitor design, the classification of proteins in this family should be considered. Three known classes of aurora kinases in mammalian species can be identified including Aurora A (AURKA, Aurora2), Aurora B (AURKB, Aurora1), and Aurora C (AURKC, Aurora3).

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