MLN8054

Product Name:	MLN8054
CAT#:	DEAK-2312-LGZ-7
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

MLN8054 is an inhibitor of Aurora A kinase and can induce senescence in human tumor cells both in vivo and in vitro.

Basic Information

Synonyms:	MLN-8054
Application:	Aurora A Inhibitor
CAS Number:	869363-13-3
Formula:	C25H15ClF2N4O2
Molecular Weight:	476.9
SMILES:	C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O
*Solubility-In vitro:*	In vitro (25°C): DMSO: 91 mg/mL (190.82 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	15% Captisol: 28 mg/mL

Target Info

AuroraA: IC50:	4nM
AuroraB: IC50:	172nM
LCK: IC50:	3.2μM
PKA: IC50:	19μM
CK2: IC50:	20.5μM
Chk2: IC50:	28μM
PLK1: IC50:	53μM
Chk1: IC50:	>100μM
PKC: IC50:	>100μM
CaMKII: IC50:	>100μM
CDK2E: IC50:	>100μM
CDK1: IC50:	>100μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 20.97 mL 0.1 mM_5 mg: 104.84 mL 0.1 mM_10 mg: 209.69 mL 0.5 mM_1 mg: 4.19 mL 0.5 mM_5 mg: 20.97 mL 0.5 mM_10 mg: 41.94 mL 1 mM_1 mg: 2.1 mL 1 mM_5 mg: 10.48 mL 1 mM_10 mg: 20.97 mL 5 mM_1 mg: 0.42 mL 5 mM_5 mg: 2.1 mL 5 mM_10 mg: 4.19 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.