AZD1152-HQPA (Barasertib)

Product Name:	AZD1152-HQPA (Barasertib)
CAT#:	DEAK-2312-LGZ-3
Package:	5mg/10mg/50mg/100mg/(Barasertib) 10mM * 1mL in DMSO
Datasheet

Description

AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, and has a high specificity versus a panel of 50 other kinases. Ki values are 0.36 (Aurora B) and 1369 nM (Aurora A) respectively.

Basic Information

Synonyms:	Barasertib
Application:	Aurora Kinase B Inhibitor
CAS Number:	722544-51-6
Formula:	C26H30FN7O3
Molecular Weight:	507.7
SMILES:	CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
*Solubility-In vitro:*	In vitro (25°C): DMSO: 93 mg/mL (183.23 mM) Water: Insoluble Ethanol: 3 mg/mL (5.91 mM)
*Solubility-In vivo:*	2% DMSO+40% PEG 300+2% Tween 80+ddH2O: 6 mg/mL

Target Info

Aurora B (Cell-free assay):	0.37 nM
Aurora A (Cell-free assay):	1368 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.7 mL 0.1 mM_5 mg: 98.48 mL 0.1 mM_10 mg: 196.97 mL 0.5 mM_1 mg: 3.94 mL 0.5 mM_5 mg: 19.7 mL 0.5 mM_10 mg: 39.39 mL 1 mM_1 mg: 1.97 mL 1 mM_5 mg: 9.85 mL 1 mM_10 mg: 19.7 mL 5 mM_1 mg: 0.39 mL 5 mM_5 mg: 1.97 mL 5 mM_10 mg: 3.94 mL

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