VX-680 (MK-0457, Tozasertib)

Product Name:	VX-680 (MK-0457, Tozasertib)
CAT#:	DEAK-2312-LGZ-10
Package:	25mg/50mg/100mg/250mg/10mM * 1mL in DMSO
Datasheet

Description

VX-680 is a small-molecule inhibitor of the Aurora kinases.

Basic Information

Application:	Aurora Kinase Inhibitor
CAS Number:	639089-54-6
Formula:	C23H28N8OS
Molecular Weight:	464.6
SMILES:	CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
*Solubility-In vitro:*	In vitro (25°C): DMSO: 90 mg/mL (193.71 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	5% DMSO+30% PEG 300+2% Tween 80+ddH2O: 14 mg/mL

Target Info

Aurora A (Cell-free assay):	0.6 nM(Ki app)
Aurora C (Cell-free assay):	4.6 nM(Ki app)
Aurora B (Cell-free assay):	18 nM(Ki app)
FLT3 (Cell-free assay):	30 nM(Ki)
Bcr-Abl (Cell-free assay):	30 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 21.52 mL 0.1 mM_5 mg: 107.62 mL 0.1 mM_10 mg: 215.24 mL 0.5 mM_1 mg: 4.3 mL 0.5 mM_5 mg: 21.52 mL 0.5 mM_10 mg: 43.05 mL 1 mM_1 mg: 2.15 mL 1 mM_5 mg: 10.76 mL 1 mM_10 mg: 21.52 mL 5 mM_1 mg: 0.43 mL 5 mM_5 mg: 2.15 mL 5 mM_10 mg: 4.3 mL

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