MLN8237 (Alisertib)

Product Name:	MLN8237 (Alisertib)
CAT#:	DEAK-2312-LGZ-1
Package:	5mg/10mg/50mg/200mg/10mM * 1mL in DMSO
Datasheet

Description

MLN8237 (Alisertib) is a highly selective Aurora A inhibitor with an IC50 of 1.2 nM in a cell-free assay. It exhibits more than 200-fold greater selectivity for Aurora A over Aurora B.

Basic Information

Synonyms:	Alisertib
Application:	Aurora A Kinase Inhibitor
CAS Number:	1028486-01-2
Formula:	C27H20ClFN4O4
Molecular Weight:	518.9
SMILES:	COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
*Solubility-In vitro:*	In vitro (25°C) DMSO: 23 mg/mL (44.32 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	5%DMSO+30% PEG300+5%Tween-80+ddH2O: 5 mg/mL

Target Info

Aurora A:	1.2 nM (IC50)
Aurora B:	396.5 nM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.27 mL 0.1 mM_5 mg: 96.36 mL 0.1 mM_10 mg: 192.72 mL 0.5 mM_1 mg: 3.85 mL 0.5 mM_5 mg: 19.27 mL 0.5 mM_10 mg: 38.54 mL 1 mM_1 mg: 1.93 mL 1 mM_5 mg: 9.64 mL 1 mM_10 mg: 19.27 mL 5 mM_1 mg: 0.39 mL 5 mM_5 mg: 1.93 mL 5 mM_10 mg: 3.85 mL

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