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DNA Methyltransferases

DNA Methyltransferases

DNA methylation is an epigenetic modification that contributes to transcriptional regulation during normal development. The DNA methyltransferase (DNMT) family consists of the catalytically active DNMT1, DNMT3A, and DNMT3B, which methylate cytosine within CpG dinucleotides. A large number of studies have shown that DNA methylation can cause changes in chromatin structure, DNA conformation, DNA stability, and the interaction between DNA and proteins, thereby controlling gene expression.

The idea of inhibiting or killing tumor cells by blocking the hypermethylation of DNA by inhibiting the activity of DNA methyltransferase has been paid more and more attention by researchers. The study of DNA methyltransferase inhibitors has become a research hotspot in epigenetics.

For more details about our DNA methyltransferases, please click the links listed below.

  • Zebularine
  • CAT#:

    DEDM-2312-LGZ-3

  • Application:

    DNA Methyltransferase Inhibitor

  • CAS Number:

    654065

  • Lomeguatrib
  • CAT#:

    DEDM-2312-LGZ-5

  • Application:

    MGMT Inhibitor

  • CAS Number:

    192441-08-0

  • RG108
  • CAT#:

    DEDM-2312-LGZ-6

  • Application:

    DNA Methyltransferase Inhibitor

  • CAS Number:

    48208-26-0

  • O6-Benzylguanine
  • CAT#:

    DEDM-2312-LGZ-8

  • Application:

    MGMT Inhibitor

  • CAS Number:

    19916-73-5

  • SGI 1027
  • CAT#:

    DEDM-2312-LGZ-9

  • Application:

    DNMT Inhibitor

  • CAS Number:

    1020149-73-8

  • CM-272
  • CAT#:

    DEDM-2312-LGZ-10

  • Application:

    G9a/DNMT Inhibitor

  • CAS Number:

    1846570-31-7

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