CM-272

Product Name:	CM-272
CAT#:	DEDM-2312-LGZ-10
Package:	5mg/10mg/50mg/100mg
Datasheet

Description

CM-272 is a reversible dual small molecule inhibitor of G9a and DNMTs in hematological malignancies.

Basic Information

Synonyms:	CM272; CM 272
Application:	G9a/DNMT Inhibitor
CAS Number:	1846570-31-7
Formula:	C28H38N4O3
Molecular Weight:	478.63
SMILES:	CN1CCC(NC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1
*Solubility-In vitro:*	DMSO: 95 mg/mL (198.48 mM) Water: Insoluble Ethanol: 95 mg/mL (198.48 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

G9a:	8 nM (IC50)
DNMT1:	382 nM (IC50)
DNMT3A:	85 nM (IC50)
DNMT3B:	1200 nM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 20.89 mL 0.1 mM_5 mg: 104.46 mL 0.1 mM_10 mg: 208.93 mL 0.5 mM_1 mg: 4.18 mL 0.5 mM_5 mg: 20.89 mL 0.5 mM_10 mg: 41.79 mL 1 mM_1 mg: 2.09 mL 1 mM_5 mg: 10.45 mL 1 mM_10 mg: 20.89 mL 5 mM_1 mg: 0.42 mL 5 mM_5 mg: 2.09 mL 5 mM_10 mg: 4.18 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.