SGI 1027

Product Name:	SGI 1027
CAT#:	DEDM-2312-LGZ-9
Package:	10mg/25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

SGI 1027 is a DNMT inhibitor, its IC50 values are 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.

Basic Information

Synonyms:	SGI-1027; SGI1027
Application:	DNMT Inhibitor
CAS Number:	1020149-73-8
Formula:	C27H23N7O
Molecular Weight:	461.52
SMILES:	CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
*Solubility-In vitro:*	In vitro (25°C): DMSO: 85 mg/mL (184.17 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+30% PEG 300+2% Tween 80+ddH2O: 1 mg/mL

Target Info

DNMT1 (Cell-free assay):	6 μM
DNMT3B (Cell-free assay):	7.5 μM
DNMT3A (Cell-free assay):	8 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 21.67 mL 0.1 mM_5 mg: 108.34 mL 0.1 mM_10 mg: 216.68 mL 0.5 mM_1 mg: 4.33 mL 0.5 mM_5 mg: 21.67 mL 0.5 mM_10 mg: 43.34 mL 1 mM_1 mg: 2.17 mL 1 mM_5 mg: 10.83 mL 1 mM_10 mg: 21.67 mL 5 mM_1 mg: 0.43 mL 5 mM_5 mg: 2.17 mL 5 mM_10 mg: 4.33 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.