Lomeguatrib

Product Name:	Lomeguatrib
CAT#:	DEDM-2312-LGZ-5
Package:	10mg/25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

Lomeguatrib is a highly effective inhibitor of O6-alkylguanine-DNA-alkyltransferase.

Basic Information

Synonyms:	O6-(4-bromothenyl)guanine
Application:	MGMT Inhibitor
CAS Number:	192441-08-0
Formula:	C10H8BrN5OS
Molecular Weight:	326.17
SMILES:	C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
*Solubility-In vitro:*	DMSO: 60 mg/mL (183.95 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

O6-alkylguanine-DNA-alkyltransferas:

5 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 30.66 mL 0.1 mM_5 mg: 153.29 mL 0.1 mM_10 mg: 306.59 mL 0.5 mM_1 mg: 6.13 mL 0.5 mM_5 mg: 30.66 mL 0.5 mM_10 mg: 61.32 mL 1 mM_1 mg: 3.07 mL 1 mM_5 mg: 15.33 mL 1 mM_10 mg: 30.66 mL 5 mM_1 mg: 0.61 mL 5 mM_5 mg: 3.07 mL 5 mM_10 mg: 6.13 mL

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