Sirtuins

Sirtuins are widely distributed in cells and consist of a group of proteins, with a total of 7 subtypes SIRT1~SIRT7. The main function of sirtuins is to deacetylate proteins, an important protein modification process. Through deacetylation, sirtuins can maintain protein function and stability and participate in a variety of cellular processes.

Epigenetic and post-translational modification mechanisms have been found to control immune responses and metabolic reprogramming. Sirtuins are NAD⁺-dependent histone deacetylase enzymes that have recently been reported to play a potential role in immune responses. Therefore, sirtuins are of great significance as therapeutic targets for treating immune-related diseases and enhancing anti-tumor immunity.

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