Sirtinol

Product Name:	Sirtinol
CAT#:	DES-2312-LGZ-5
Package:	10mg/25mg/50mg
Datasheet

Description

Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM respectively in cell-free experiments.

Basic Information

Synonyms:	Sir Two Inhibitor Naphthol
Application:	Sirtuin Inhibitor
CAS Number:	410536-97-9
Formula:	C26H22N2O2
Molecular Weight:	394.47
SMILES:	O=C(N([H])C(C1=CC=CC=C1)C)C(C=CC=C2)=C2/N=C/C3=C(O)C=CC4=C3C=CC=C4
*Solubility-In vitro:*	In vitro (25°C): DMSO: 20 mg/mL (50.7 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 0.3 mg/mL

Target Info

ySir2:	48 μM (IC50)
hSIRT2:	57.7 μM (IC50)
hSIRT1:	131 μM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 25.35 mL 0.1 mM_5 mg: 126.75 mL 0.1 mM_10 mg: 253.5 mL 0.5 mM_1 mg: 5.07 mL 0.5 mM_5 mg: 25.35 mL 0.5 mM_10 mg: 50.7 mL 1 mM_1 mg: 2.54 mL 1 mM_5 mg: 12.68 mL 1 mM_10 mg: 25.35 mL 5 mM_1 mg: 0.51 mL 5 mM_5 mg: 2.54 mL 5 mM_10 mg: 5.07 mL

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