SRT 2183

Product Name:	SRT 2183
CAT#:	DES-2312-LGZ-4
Package:	50mg/5mg/10mg
Datasheet

Description

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.

Basic Information

Synonyms:	SRT2183; SRT-2183
Application:	Sirtuin-1 (SIRT1) Activator
CAS Number:	1001908-89-9
Formula:	C27H24N4O2S
Molecular Weight:	468.57
SMILES:	O=C(NC1=C(C2=CN3C(SC=C3CN4CC[C@@H](O)C4)=N2)C=CC=C1)C(C=C5)=CC6=C5C=CC=C6
*Solubility-In vitro:*	DMSO: 86 mg/mL (183.53 mM) Water: Insoluble Ethanol: 3 mg/mL (6.4 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

SIRT1:

0.36 μM (EC1.5)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 21.34 mL 0.1 mM_5 mg: 106.71 mL 0.1 mM_10 mg: 213.42 mL 0.5 mM_1 mg: 4.27 mL 0.5 mM_5 mg: 21.34 mL 0.5 mM_10 mg: 42.68 mL 1 mM_1 mg: 2.13 mL 1 mM_5 mg: 10.67 mL 1 mM_10 mg: 21.34 mL 5 mM_1 mg: 0.43 mL 5 mM_5 mg: 2.13 mL 5 mM_10 mg: 4.27 mL

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