EX 527 (Selisistat)

Product Name:	EX 527 (Selisistat)
CAT#:	DES-2312-LGZ-1
Package:	5mg/10mg/25mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

EX 527 is a highly effective and selective SIRT1 class III histone deacetylase enzyme inhibitor in a cell-free assay, and IC50 is 38 nM.

Basic Information

Synonyms:	EX527; EX-527
Application:	SIRT1 Inhibitor
CAS Number:	49843-98-3
Formula:	C13H13ClN2O
Molecular Weight:	248.7
SMILES:	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
*Solubility-In vitro:*	In vitro (25°C): DMSO: 46 mg/mL (184.95 mM) Water: Insoluble Ethanol: 17 mg/mL (68.35 mM)
*Solubility-In vivo:*	5% DMSO+30% PEG 300+ddH2O: 14 mg/mL

Target Info

SIRT1 (Cell-free assay):

38 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 40.21 mL 0.1 mM_5 mg: 201.05 mL 0.1 mM_10 mg: 402.09 mL 0.5 mM_1 mg: 8.04 mL 0.5 mM_5 mg: 40.21 mL 0.5 mM_10 mg: 80.42 mL 1 mM_1 mg: 4.02 mL 1 mM_5 mg: 20.1 mL 1 mM_10 mg: 40.21 mL 5 mM_1 mg: 0.8 mL 5 mM_5 mg: 4.02 mL 5 mM_10 mg: 8.04 mL

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