17-AAG (KOS953)

Product Name:	17-AAG (KOS953)
CAT#:	DMMRP-2312-LGZ-1
Package:	10mg/100mg/200mg/50mg/(KOS953) 10mM * 1mL in DMSO
Datasheet

Description

17-AAG is an ansamycin antibiotic with anti-tumor effects. 17-AAG binds to Hsp90 and inhibits its expression.

Basic Information

Synonyms:	Tanespimycin; NSC330507; CP 127374; KOS-953; KOS 953
Application:	HSP90 Inhibitor
CAS Number:	75747-14-7
Formula:	C31H43N3O8
Molecular Weight:	585.7
SMILES:	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
*Solubility-In vitro:*	In vitro (25°C): DMSO: 97 mg/mL (165.61 mM) Water: Insoluble Ethanol: 5 mg/mL
*Solubility-In vivo:*	5%DMSO+corn oil: 9 mg/mL

Target Info

HSP90 (Cell-free assay):

5 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 17.07 mL 0.1 mM_5 mg: 85.37 mL 0.1 mM_10 mg: 170.74 mL 0.5 mM_1 mg: 3.41 mL 0.5 mM_5 mg: 17.07 mL 0.5 mM_10 mg: 34.15 mL 1 mM_1 mg: 1.71 mL 1 mM_5 mg: 8.54 mL 1 mM_10 mg: 17.07 mL 5 mM_1 mg: 0.34 mL 5 mM_5 mg: 1.71 mL 5 mM_10 mg: 3.41 mL

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