17-DMAG HCl (Alvespimycin)

Product Name:	17-DMAG HCl (Alvespimycin)
CAT#:	DMMRP-2312-LGZ-2
Package:	25mg/50mg/100mg/200mg/(Alvespimycin) 10mM * 1mL in DMSO
Datasheet

Description

17-DMAG shows more potent anti-tumor activity than 17-AAG and is a water-soluble analog of 17-AAG and geldanamycin, which can bind to the ATP-binding site of Hsp90 and inhibit its chaperone activity.

Basic Information

Synonyms:	17DMAG; NSC 707545
Application:	Hsp90 Inhibitor
CAS Number:	467214-21-7
Formula:	C32H48N4O8.HCl
Molecular Weight:	653.2
SMILES:	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
*Solubility-In vitro:*	In vitro (25°C): DMSO: 127 mg/mL (194.42 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	1% DMSO+30% polyethylene glycol+1% Tween 80: 28 mg/mL

Target Info

HSP90 (Cell-free assay):

62 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 15.31 mL 0.1 mM_5 mg: 76.55 mL 0.1 mM_10 mg: 153.09 mL 0.5 mM_1 mg: 3.06 mL 0.5 mM_5 mg: 15.31 mL 0.5 mM_10 mg: 30.62 mL 1 mM_1 mg: 1.53 mL 1 mM_5 mg: 7.65 mL 1 mM_10 mg: 15.31 mL 5 mM_1 mg: 0.31 mL 5 mM_5 mg: 1.53 mL 5 mM_10 mg: 3.06 mL

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