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5-Hydroxymethylcytosine (5-Hmc) DNA Matched Antibody Pair
Description
5-Hydroxymethylcytosine (5hmC) is the first oxidation product during the active demethylation of 5-methylcytosine (5mC). It not only marks active demethylation but also serves as a relatively stable DNA mark that plays different epigenetic roles. It may be important in epigenetics, as hydroxymethyl groups on cytosine have the potential to turn a gene on or off. 5hmC is highly expressed, but expression levels vary by cell type. The highest levels are found in neuronal cells of the central nervous system.
Basic Information
| Synonyms: | 5-hmC |
| Application: | Quantitative ELISA |
| Assay Type: | Sandwich |
| Crossreactivity: | All |
| Detection Type: | Colorimetric |
| Kit Contains: | 1) Capture Antibody: Anti-5-Hydroxymethylcytosine Rabbit Monoclonal Antibody, Clone RM236, 50 ug at 1.0 mg/mL in 50% Glycerol/PBS with 0.09% sodium azide, without BSA or other carrier proteins. 2) Detection Antibody: Biotin Anti-Adenine and Guanine Rabbit Monoclonal Antibody, Clone RM476, 25 ug at 1.0 mg/mL in 50% Glycerol/PBS with 0.09% sodium azide and 1% BSA |
| Quantity: | ELISA:Capture Antibody 50 µg at 1.0mg/mLDetection Antibody 25 µg at 1.0mg/mL |
Shipping and Handling
| Storage (Long Term): | -20°C |
| Shipping: | Blue Ice |
| Handling Advice: | To prevent freeze/thaw cycles, it is recommended to prepare aliquots of the compound. |
| Stability: | When stored at a temperature of -20°C, it remains stable for at least 1 year after receipt. |
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