A-966492

Product Name:	A-966492
CAT#:	DEPA-2312-LGZ-1
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

A-966492 showed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme, with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.

Basic Information

Synonyms:	A966492
Application:	PARP1 Inhibitor
CAS Number:	934162-61-5
Formula:	C18H17FN4O
Molecular Weight:	324.4
SMILES:	C1CC(NC1)C2=CC(=C(C=C2)C3=NC4=C(C=CC=C4N3)C(=O)N)F
*Solubility-In vitro:*	DMSO-Warmed: 60 mg/mL (184.98 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

PARP1:	1 nM(Ki)
PARP1:	1 nM(EC50)
PARP2:	1.5 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 30.83 mL 0.1 mM_5 mg: 154.13 mL 0.1 mM_10 mg: 308.26 mL 0.5 mM_1 mg: 6.17 mL 0.5 mM_5 mg: 30.83 mL 0.5 mM_10 mg: 61.65 mL 1 mM_1 mg: 3.08 mL 1 mM_5 mg: 15.41 mL 1 mM_10 mg: 30.83 mL 5 mM_1 mg: 0.62 mL 5 mM_5 mg: 3.08 mL 5 mM_10 mg: 6.17 mL

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