ACE2 (Human) ELISA Kit
Description
The human ACE2 gene is located on the X chromosome and encodes a protein of 805 amino acids, including an N-terminal signal sequence, a metalloproteinase zinc binding site (HEMGH), and a hydrophobic region near the C-terminal that serves as a membrane anchor (transmembrane domain). ACE2 is a type I transmembrane metallocarboxypeptidase in the renin-angiotensin system (RAS), which plays a key role in blood pressure regulation, water and electrolyte balance, thirst, heart/kidney function, growth and development. ACE2 is expressed on the cell surface of type 2 alveolar epithelial cells in the lung and on the cell surface of many other tissues. ACE2 has about 60% homology with ACE, another key enzyme of the RAS system. The effects of ACE2 directly antagonize those induced by the ACE-Ang II signaling pathway, with ACE converting Ang I to Ang II, which increases blood pressure by inducing vasoconstriction, increasing renal reabsorption of sodium and water, and promoting inflammation.
Basic Information
| Synonyms: | SARS-CoV-2 Receptor; Angiotensin-converting Enzyme 2; Angiotensin-converting Enzyme Homolog; Angiotensin-converting Enzyme-related Carboxypeptidase; Metalloprotease MPROT15 |
| Application: | Quantitative ELISA |
| Assay Type: | Sandwich |
| Crossreactivity: | Human |
| Detection Type: | Colorimetric |
| Quantity: | 1 x 96 wells |
| Range: | 0.0625 to 4 ng/ml |
| Sample Type: | Cell Culture Supernatant; Plasma; Serum; Urine |
| Sensitivity: | 40 pg/ml |
Shipping and Handling
| Storage (Short Term): | 4°C |
| Storage (Long Term): | 4°C |
| Shipping: | Blue Ice |
| Handling Advice: | After standard reconstitution, prepare aliquots and store at -20°C. To prevent freeze/thaw cycles, it is recommended to prepare aliquots of the compound. Plate and reagents should reach room temperature before use. |
| Stability: | See expiry date on ELISA Kit box. 12 months after the day of manufacturing. |
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
