AG-014699 (Rucaparib)

Product Name:	AG-014699 (Rucaparib)
CAT#:	DEPA-2312-LGZ-3
Package:	5mg/25mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

AG-014699 (Rucaparib) can inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.

Basic Information

Synonyms:	AG014699; PF-01367338,AG-014447 (As Free Base)
Application:	PARP Inhibitor
CAS Number:	459868-92-9
Formula:	C19H18FN3O.H3PO4
Molecular Weight:	421.4
SMILES:	CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O
*Solubility-In vitro:*	In vitro (25°C) DMSO: 81 mg/mL (192.23 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+30% PEG 300+2% Tween 80+ddH2O: 9 mg/mL

Target Info

PARP (Cell-free assay):

1.4 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 23.73 mL 0.1 mM_5 mg: 118.65 mL 0.1 mM_10 mg: 237.3 mL 0.5 mM_1 mg: 4.75 mL 0.5 mM_5 mg: 23.73 mL 0.5 mM_10 mg: 47.46 mL 1 mM_1 mg: 2.37 mL 1 mM_5 mg: 11.87 mL 1 mM_10 mg: 23.73 mL 5 mM_1 mg: 0.47 mL 5 mM_5 mg: 2.37 mL 5 mM_10 mg: 4.75 mL

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