AG14361

Product Name:	AG14361
CAT#:	DEPA-2312-LGZ-4
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

AG14361 can enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.

Basic Information

Synonyms:	AG-14361
Application:	PARP Inhibitor
CAS Number:	328543-09-5
Formula:	C19H20N4O
Molecular Weight:	320.4
SMILES:	CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O
*Solubility-In vitro:*	In vitro (25°C): DMSO: 11 mg/mL (34.33 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	4% DMSO+ddH2O: 1 mg/mL

Target Info

PARP1 (Cell-free assay):

<5 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 31.21 mL 0.1 mM_5 mg: 156.05 mL 0.1 mM_10 mg: 312.11 mL 0.5 mM_1 mg: 6.24 mL 0.5 mM_5 mg: 31.21 mL 0.5 mM_10 mg: 62.42 mL 1 mM_1 mg: 3.12 mL 1 mM_5 mg: 15.61 mL 1 mM_10 mg: 31.21 mL 5 mM_1 mg: 0.62 mL 5 mM_5 mg: 3.12 mL 5 mM_10 mg: 6.24 mL

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