ALKBH8 Polyclonal Antibody, Unconjugated
Description
ALKBH8 is a protein consisting of 664 amino acids and is encoded by a gene located on chromosome 11. It belongs to the AlkB family of proteins and contains one RNA recognition motif (RRM) domain. ALKBH8 is a homolog of the Escherichia coli protein AlkB. The main function of ALKBH8 is to protect DNA and RNA from damage caused by methylating compounds present in the environment. It achieves this by directly reversing cytotoxic alkylation lesions, specifically 1-methyladenine (1-meA) and 3-methylcytosine (3-meC), in both DNA and RNA molecules. To carry out its enzymatic activity, ALKBH8 utilizes ferrous iron and alpha-ketoglutarate as cofactors, with 2-oxoglutarate serving as a co-substrate. Molecular oxygen acts as the oxidizing agent during oxidative demethylation. It's worth noting that there are three isoforms of ALKBH8 due to alternative splicing events occurring in the gene.
Basic Information
| Synonyms: | 4930562C03Rik, 9430088N01Rik, 8030431D03Rik, alkB alkylation repair homolog 8 (E. coli), ABH8, alkB alkylation repair homolog 8, ALKB8, AlkB homologue 8, ALKB8, ALKBH8, Alkylated DNA repair protein alkB homolog 8, MGC10235, FLJ38204, OTTHUMP00000211286, OTTHUMP00000211287, RGD1304687, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 |
| Application: | WB/IHC/ELISA |
| Label/Conjugates: | Unconjugated |
| Crossreactivity: | Human |
| Source/Host: | Rabbit |
| Uniprot: | Q96BT7 |
| Accession: | BC015183 |
| Buffer: | 40% Glycerol, PBS with 0.05% NaN3, pH7.4 |
| Concentration: | 0.6 mg/mL |
| Isotype: | IgG |
| Purification: | Antigen affinity purification |
Immunogen Properties
| Abbre: | ALKBH8 |
| Calculated MW: | 75 kDa |
| Clonality: | Polyclonal |
| Immunogen: | Full length fusion protein |
Shipping and Handling
| Stability & Storage: | Store the sample at a temperature of -20°C and avoid subjecting it to repeated freeze/thaw cycles. |
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