AMI-1

Product Name:	AMI-1
CAT#:	DEPAM-2312-LGZ-8
Package:	5mg/10mg/25mg
Datasheet

Description

AMI-1 is a highly effective and specific inhibitor of Histone Methyltransferase (HMT) (IC50 values are 3.0 uM and 8.8 uM for yeast Hmt1p and human PRMT1, respectively).

Basic Information

Synonyms:	AMI 1; AMI1; AMI-1 disodium salt
Application:	Hmt1p/PRMT1 Inhibitor
CAS Number:	20324-87-2
Formula:	C21H14N2Na2O9S2
Molecular Weight:	548.45
SMILES:	O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 89 mg/mL (162.27 mM) Water: 9 mg/mL (16.41 mM) Ethanol: Insoluble
*Solubility-In vivo:*	PBS: 20 mg/mL

Target Info

yeast Hmt1p:	3.0 μM
human PRMT1:	8.8 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 18.23 mL 0.1 mM_5 mg: 91.17 mL 0.1 mM_10 mg: 182.33 mL 0.5 mM_1 mg: 3.65 mL 0.5 mM_5 mg: 18.23 mL 0.5 mM_10 mg: 36.47 mL 1 mM_1 mg: 1.82 mL 1 mM_5 mg: 9.12 mL 1 mM_10 mg: 18.23 mL 5 mM_1 mg: 0.36 mL 5 mM_5 mg: 1.82 mL 5 mM_10 mg: 3.65 mL

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