Annexin V (Human), ≥95% (SDS-PAGE)
Description
Annexin V is an anticoagulant protein that indirectly inhibits the thromboplastin-specific complex, a component of the blood coagulation cascade. It achieves this by competing for binding sites, particularly phosphatidylserine binding sites found on platelets, with prothrombin and coagulation factors. Annexin V also inhibits the activity of phospholipase A1. In patients with antiphospholipid syndrome (APS), an autoimmune disorder associated with thrombophilia, antibodies against annexin V can be detected. These antibodies target phospholipid compounds. Annexin V serves as a valuable tool in the annexin V affinity assay, where it is used to identify cells that have expressed phosphatidylserine on their cell surface. This feature is observed in apoptosis and other forms of cell death.
Basic Information
| Molecular Weight: | ~52kDa (SDS-PAGE) |
| Synonyms: | Annexin A5; Endonexin II; Lipocortin V; Placental Anticoagulant Protein I; Calphobindin I; Vascular Anticoagulant-α |
| Concentration: | 1mg/ml after reconstitution. |
| Crossreactivity: | Human |
| Formulation: | Lyophilized. In PBS. |
| Purity: | ≥95% (SDS-PAGE) |
| Purity Detail: | Affinity purified. |
| Sequence: | Recombinant human annexin V fused to a GST-tag. |
| Source/Host: | E. coli |
Shipping and Handling
| Storage (Short Term): | 4°C |
| Storage (Long Term): | -20°C |
| Shipping: | Blue Ice |
| Handling Advice: | To prevent freeze/thaw cycles, it is recommended to prepare aliquots of the compound. Centrifuge lyophilized vial before opening and reconstitution. Repeated freeze/thaw cycles (>3) may result in an adverse effect on the activity. |
| Stability: | When stored at a temperature of -20°C, it remains stable for at least 1 year after receipt. Reconstituted solutions can be kept at 4°C under sterile conditions for one week or should be frozen in aliquots at -20°C. |
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