Apixaban (BMS-562247-01)

Product Name:	Apixaban (BMS-562247-01)
CAT#:	DMMRP-2312-LGZ-5
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

Apixaban is an anticoagulant used to prevent venous thromboembolism and venous thromboembolic events.

Basic Information

Synonyms:	BMS-562247-01
Application:	Factor Xa Inhibitor
CAS Number:	503612-47-3
Formula:	C25H25N5O4
Molecular Weight:	459.5
SMILES:	COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
*Solubility-In vitro:*	In vitro (25°C): DMSO: 17 mg/mL (36.99 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	30% PEG 400+0.5% Tween 80+5% Propylene glycol: 28 mg/mL

Target Info

Factor Xa (human) (Cell-free assay):	0.08 nM(Ki)
Factor Xa (rabbit) (Cell-free assay):	0.17 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 21.76 mL 0.1 mM_5 mg: 108.81 mL 0.1 mM_10 mg: 217.63 mL 0.5 mM_1 mg: 4.35 mL 0.5 mM_5 mg: 21.76 mL 0.5 mM_10 mg: 43.53 mL 1 mM_1 mg: 2.18 mL 1 mM_5 mg: 10.88 mL 1 mM_10 mg: 21.76 mL 5 mM_1 mg: 0.44 mL 5 mM_5 mg: 2.18 mL 5 mM_10 mg: 4.35 mL

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