Ascomycin

Product Name:	Ascomycin
CAT#:	DEPSP-2312-LGZ-1
Package:	10mg/25mg/10mM * 1mL in DMSO
Datasheet

Description

is a highly effective immunosuppressant and may serve as a highly effectiveial treatment for autoimmune diseases.

Basic Information

Synonyms:	FK 520; FR 900520; FK520; FR900520
Application:	Calcineurin Inhibitor
CAS Number:	104987-12-4
Formula:	C43H69NO12
Molecular Weight:	792.01
SMILES:	CC[C@@H]1/C=C(/C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)\C
*Solubility-In vitro:*	DMSO: 98 mg/mL (123.73 mM) Water: Insoluble Ethanol: 98 mg/mL (123.73 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

calcineurin phosphatase:

49 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 12.63 mL 0.1 mM_5 mg: 63.13 mL 0.1 mM_10 mg: 126.26 mL 0.5 mM_1 mg: 2.53 mL 0.5 mM_5 mg: 12.63 mL 0.5 mM_10 mg: 25.25 mL 1 mM_1 mg: 1.26 mL 1 mM_5 mg: 6.31 mL 1 mM_10 mg: 12.63 mL 5 mM_1 mg: 0.25 mL 5 mM_5 mg: 1.26 mL 5 mM_10 mg: 2.53 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.