Avasimibe (CI-1011)

Product Name:	Avasimibe (CI-1011)
CAT#:	DMME-2312-LGZ-8
Package:	10mg/50mg/100mg/200mg/(CI-1011) 10mM * 1mL in DMSO
Datasheet

Description

Avasimibe is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.

Basic Information

Synonyms:	CI-1011; CI1011; PD 148515
Application:	CYP17 Inhibitor
CAS Number:	166518-60-1
Formula:	C29H43NO4S
Molecular Weight:	501.7
SMILES:	CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C
*Solubility-In vitro:*	In vitro (25°C): DMSO: 96 mg/mL (191.34 mM) Water: Insoluble Ethanol: 8 mg/mL (15.94 mM)
*Solubility-In vivo:*	2% DMSO+corn oil: 4 mg/mL

Target Info

CYP2C9:	2.9 μM
ACAT:	3.3 μM
CYP1A2:	13.9 μM
CYP2C19:	26.5 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.93 mL 0.1 mM_5 mg: 99.66 mL 0.1 mM_10 mg: 199.32 mL 0.5 mM_1 mg: 3.99 mL 0.5 mM_5 mg: 19.93 mL 0.5 mM_10 mg: 39.86 mL 1 mM_1 mg: 1.99 mL 1 mM_5 mg: 9.97 mL 1 mM_10 mg: 19.93 mL 5 mM_1 mg: 0.4 mL 5 mM_5 mg: 1.99 mL 5 mM_10 mg: 3.99 mL

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