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AZ-960
Description
AZ-960 is a highly effective, selective and ATP competitive JAK2 inhibitor, can inhibit JAK2 kinase with a Ki of 0.45 nM in vitro and induce growth arrest and apoptosis in adult T-cell leukemia (ATL) cell.
Basic Information
| Synonyms: | AZ960 |
| Application: | JAK2Inhibitor |
| CAS Number: | 905586-69-8 |
| Formula: | C18H16F2N6 |
| Molecular Weight: | 354.4 |
| SMILES: | CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F |
| Solubility-In vitro: | DMSO: 70 mg/mL (197.54 mM) Water: Insoluble Ethanol: 3 mg/mL (8.46 mM) * <1 mg/ml means slightly soluble or insoluble. |
Target Info
| JAK2: | 0.45 nM(Ki) |
| JAK2: | <3 nM |
Storage
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Preparing Stock Solutions
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0.1 mM_1 mg: 28.22 mL
0.1 mM_5 mg: 141.08 mL
0.1 mM_10 mg: 282.17 mL
0.5 mM_1 mg: 5.64 mL
0.5 mM_5 mg: 28.22 mL
0.5 mM_10 mg: 56.43 mL
1 mM_1 mg: 2.82 mL
1 mM_5 mg: 14.11 mL
1 mM_10 mg: 28.22 mL
5 mM_1 mg: 0.56 mL
5 mM_5 mg: 2.82 mL
5 mM_10 mg: 5.64 mL
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