AZD1480

Product Name:	AZD1480
CAT#:	DEJ-2312-LGZ-2
Package:	5mg/10mg/50mg/200mg/10mM * 1mL in DMSO
Datasheet

Description

AZD1480 is a novel potent small JAK2 inhibitor, IC50 is 0.26 nM.

Basic Information

Application:	JAK Inhibitor
CAS Number:	935666-88-9
Formula:	C14H14ClFN8
Molecular Weight:	348.8
SMILES:	CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 68 mg/mL (194.96 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	30% PEG400+0.5% Tween80+5% propylene glycol: 4 mg/mL

Target Info

JAK2 (Cell-free assay):

0.26 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 28.67 mL 0.1 mM_5 mg: 143.35 mL 0.1 mM_10 mg: 286.7 mL 0.5 mM_1 mg: 5.73 mL 0.5 mM_5 mg: 28.67 mL 0.5 mM_10 mg: 57.34 mL 1 mM_1 mg: 2.87 mL 1 mM_5 mg: 14.33 mL 1 mM_10 mg: 28.67 mL 5 mM_1 mg: 0.57 mL 5 mM_5 mg: 2.87 mL 5 mM_10 mg: 5.73 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.