BAY-876

Product Name:	BAY-876
CAT#:	DMG-2312-LGZ-3
Package:	2mg/5mg/10mg/ 50mg
Datasheet

Description

BAY-876 is a highly efficient and selective GLUT1 inhibitor with good metabolic stability in vitro and high oral bioavailability in vivo.

Basic Information

Synonyms:	BAY 876; BAY876
Application:	GLUT1 Inhibitor
CAS Number:	1799753-84-6
Formula:	C24H16F4N6O2
Molecular Weight:	496.4256
SMILES:	O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C=C4)C#N)N=C3C(F)(F)F)=O)=C1)N
*Solubility-In vitro:*	DMSO: Warmed: 88 mg/mL (177.26 mM) Water: Insoluble Ethanol: Warmed: 3 mg/mL (6.04 mM) * <1 mg/ml means slightly soluble or insoluble.

Target Info

GLUT1:	2 nM (IC50)
GLUT2:	10.08 μM (IC50)
GLUT3:	1.67 μM (IC50)
GLUT4:	0.29 μM (IC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 20.14 mL 0.1 mM_5 mg: 100.72 mL 0.1 mM_10 mg: 201.44 mL 0.5 mM_1 mg: 4.03 mL 0.5 mM_5 mg: 20.14 mL 0.5 mM_10 mg: 40.29 mL 1 mM_1 mg: 2.01 mL 1 mM_5 mg: 10.07 mL 1 mM_10 mg: 20.14 mL 5 mM_1 mg: 0.4 mL 5 mM_5 mg: 2.01 mL 5 mM_10 mg: 4.03 mL

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