Belinostat (PXD101)

Product Name:	Belinostat (PXD101)
CAT#:	DEH-2312-LGZ-1
Package:	10mg/50mg/100mg/200mg/(PXD101) 10mM * 1mL in DMSO
Datasheet

Description

Belinostat (PXD101) inhibits HDAC activity in HeLa cell extracts and IC50 is 27 nM.

Basic Information

Synonyms:	PX105684
Application:	HDAC Inhibitor
CAS Number:	414864-00-9
Formula:	C15H14N2O4S
Molecular Weight:	318.4
SMILES:	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO
*Solubility-In vitro:*	In vitro (25°C): DMSO: 56 mg/mL (175.9 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+30% PEG 300+ddH2O: 9 mg/mL

Target Info

HDAC (Cell-free assay):

27 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 31.41 mL 0.1 mM_5 mg: 157.04 mL 0.1 mM_10 mg: 314.07 mL 0.5 mM_1 mg: 6.28 mL 0.5 mM_5 mg: 31.41 mL 0.5 mM_10 mg: 62.81 mL 1 mM_1 mg: 3.14 mL 1 mM_5 mg: 15.7 mL 1 mM_10 mg: 31.41 mL 5 mM_1 mg: 0.63 mL 5 mM_5 mg: 3.14 mL 5 mM_10 mg: 6.28 mL

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