(-)-Bicuculline MethLodide
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Description
(-)-Bicuculline methiodide is a soluble variant of the primary ionotropic GABAA receptor blocker (+)-Bicuculline. As a pioneering and aggressive GABAA receptor antagonist, it displaces GABA from the binding site of the agonist, thus inhibiting receptor activation. It also serves as a negative allosteric inhibitor of channel opening to hinder the activation of the GABAA receptor by anesthetics. Additionally, it shows activity at SK calcium-activated potassium channels, nicotinic acetylcholine receptors, and acetylcholinesterase. This compound blocks currents mediated by the GABAA receptor in a reversible and competitive manner, and is frequently used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).
Basic Information
| CAS Number: | 40709-69-1 |
| Formula: | C21H20INO6 |
| Molecular Weight: | 509.29 |
| Synonyms: | N-Methylbicuculline iodide; 55950-07-7 |
| InChi Key: | HKJKCPKPSSVUHY-GRTNUQQKSA-M |
| Appearance: | White to off-white powder |
| Identity: | Determined by 1H-NMR. |
| Purity Chemicals: | ≥95% (NMR) |
| SMILES: | C[N+]1(C)[C@@]([C@@]2([H])C(C=CC3=C4OCO3)=C4C(O2)=O)([H])C5=CC6=C(OCO6)C=C5CC1.[I-] |
| Solubility: | Soluble in water (10 mg/ml) or DMSO (30 mg/ml). |
Shipping and Handling
| Storage (Short Term): | 20°C |
| Storage (Long Term): | 4°C |
| Shipping: | Ambient |
| Handling Advice: | Protect from moisture and light. |
| Stability: | When stored at a temperature of +4°C, it remains stable for at least 2 years. |
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