BIIB021

Product Name:	BIIB021
CAT#:	DMMRP-2312-LGZ-6
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

BIIB021 is an oral, fully synthetic Hsp90 inhibitor that selectively and effectively inhibits the molecular chaperone Hsp90, thereby inhibiting the correct assembly of multiple oncogenic proteins involved in tumor growth and survival.

Basic Information

Synonyms:	CNF2024
Application:	HSP90 Inhibitor
CAS Number:	848695-25-0
Formula:	C14H15ClN6O
Molecular Weight:	318.8
SMILES:	CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
*Solubility-In vitro:*	In vitro (25°C): DMSO: 60 mg/mL (188.22 mM) Water: Insoluble Ethanol: 2 mg/mL (6.27 mM)
*Solubility-In vivo:*	30% propylene glycol, 5% Tween 80, 65% D5W: 28 mg/mL

Target Info

HSP90:	1.7 nM(Ki)
HSP90:	38 nM(EC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 31.37 mL 0.1 mM_5 mg: 156.84 mL 0.1 mM_10 mg: 313.68 mL 0.5 mM_1 mg: 6.27 mL 0.5 mM_5 mg: 31.37 mL 0.5 mM_10 mg: 62.74 mL 1 mM_1 mg: 3.14 mL 1 mM_5 mg: 15.68 mL 1 mM_10 mg: 31.37 mL 5 mM_1 mg: 0.63 mL 5 mM_5 mg: 3.14 mL 5 mM_10 mg: 6.27 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.