Capecitabine (Xeloda)

Product Name:	Capecitabine (Xeloda)
CAT#:	DMA-2312-LGZ-2
Package:	1g/5g/(Xeloda) 10mM * 1mL in DMSO
Datasheet

Description

Capecitabine is a prodrug that is enzymatically converted into 5-fluorouracil in tumors, thereby inhibiting DNA synthesis and slowing down the growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil.

Basic Information

Synonyms:	Captabin
CAS Number:	154361-50-9
Formula:	C15H22FN3O6
Molecular Weight:	359.4
SMILES:	CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[C@H]2[C@@H]([C@@H]([C@H](O2)C)O)O
*Solubility-In vitro:*	DMSO: 62 mg/mL (172.53 mM) Water: 5 mg/mL (13.91 mM) Ethanol: 62 mg/mL (172.53 mM) * <1 mg/ml means slightly soluble or insoluble.

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 27.82 mL 0.1 mM_5 mg: 139.12 mL 0.1 mM_10 mg: 278.24 mL 0.5 mM_1 mg: 5.56 mL 0.5 mM_5 mg: 27.82 mL 0.5 mM_10 mg: 55.65 mL 1 mM_1 mg: 2.78 mL 1 mM_5 mg: 13.91 mL 1 mM_10 mg: 27.82 mL 5 mM_1 mg: 0.56 mL 5 mM_5 mg: 2.78 mL 5 mM_10 mg: 5.56 mL

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