Chaetocin

Product Name:	Chaetocin
CAT#:	DEHM-2312-LGZ-10
Package:	1mg/2mg/5mg/10mg
Datasheet

Description

Chaetocin is an inhibitor of histone methyltransferase SUV39H1, with an IC50 value of 0.8 μM. Induces apoptosis in myeloma cell lines in vitro and exhibits antiproliferative activity in mouse myeloma models in vivo.

Basic Information

Application:	SUV39H HMT Inhibitor
CAS Number:	28097-03-2
Formula:	C30H28N6O6S4
Molecular Weight:	696.84
SMILES:	CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
*Solubility-In vitro:*	DMSO: Warmed: 87 mg/mL (124.85 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

dSU(VAR)3-9:	0.8 μM
mouse G9a:	2.5 μM
Neurospora crassa DIM5:	3 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 14.35 mL 0.1 mM_5 mg: 71.75 mL 0.1 mM_10 mg: 143.5 mL 0.5 mM_1 mg: 2.87 mL 0.5 mM_5 mg: 14.35 mL 0.5 mM_10 mg: 28.7 mL 1 mM_1 mg: 1.44 mL 1 mM_5 mg: 7.18 mL 1 mM_10 mg: 14.35 mL 5 mM_1 mg: 0.29 mL 5 mM_5 mg: 1.44 mL 5 mM_10 mg: 2.87 mL

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