Cladribine

Product Name:	Cladribine
CAT#:	DMA-2312-LGZ-4
Package:	25mg/50mg/100mg/200mg/10mM * 1mL in DMSO
Datasheet

Description

Cladribine is a synthetic anticancer drug that mimics the nucleoside adenosine, thereby inhibiting adenosine deaminase, which interferes with cells' ability to process DNA.

Basic Information

Synonyms:	2-chlorodeoxyadenosine; Leustatin
CAS Number:	4291-63-8
Formula:	C10H12ClN5O3
Molecular Weight:	285.7
SMILES:	C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(N=C3N)Cl)CO)O
*Solubility-In vitro:*	In vitro (25°C): DMSO: 52 mg/mL (182.01 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	5% DMSO+30% PEG 300+1% Tween 80+H2O: 9 mg/mL

Target Info

Adenosine deaminase (MM1.S cells):	0.18 μM
Adenosine deaminase (RPMI8226 cells):	0.75 μM
Adenosine deaminase (U266 cells):	2.43 μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 35 mL 0.1 mM_5 mg: 175.01 mL 0.1 mM_10 mg: 350.02 mL 0.5 mM_1 mg: 7 mL 0.5 mM_5 mg: 35 mL 0.5 mM_10 mg: 70 mL 1 mM_1 mg: 3.5 mL 1 mM_5 mg: 17.5 mL 1 mM_10 mg: 35 mL 5 mM_1 mg: 0.7 mL 5 mM_5 mg: 3.5 mL 5 mM_10 mg: 7 mL

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