CP-690550 (Tofacitinib Citrate)

Product Name:	CP-690550 (Tofacitinib Citrate)
CAT#:	DEJ-2312-LGZ-3
Package:	10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

CP-690550 (Tofacitinib citrate) is a highly selective inhibitor of the Janus kinase (JAK) family of enzymes, and it is an orally available.

Basic Information

Synonyms:	CP690550; Tasocitinib Citrate; CP-690,550
Application:	JAK3 Inhibitor
CAS Number:	540737-29-9
Formula:	C16H20N6O.C6H8O7
Molecular Weight:	504.5
SMILES:	C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 94 mg/mL (186.32 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	0.5% methylcellulose: 28 mg/mL

Target Info

JAK3: IC50:	1nM
JAK2: IC50:	20nM
JAK1: IC50:	112nM
ROCK2: IC50:	3.4μM
LCK: IC50:	3.87μM
IRK: IC50:	>10μM
CDK2: IC50:	>10μM
CDK5: IC50:	>10μM
EGFR: IC50:	>10μM
MAPK2/ERK2: IC50:	>10μM
JNK1/SAPK1c: IC50:	>10μM
SAPK2a/p38: IC50:	>10μM
SAPK2b/p38b2: IC50:	>10μM
SAPK3/p38g: IC50:	>10μM
SAPK4/p38d: IC50:	>10μM
MAPKAPK2: IC50:	>10μM
MAPKAP-K1b: IC50:	>10μM
MSK1: IC50:	>10μM
PRAK: IC50:	>10μM
PKA: IC50:	>10μM
PKCα: IC50:	>10μM
PDK-1: IC50:	>10μM
PKBα: IC50:	>10μM
SGK: IC50:	>10μM
p70S6K: IC50:	>10μM
GSK-3β: IC50:	>10μM
AMPK: IC50:	>10μM
Chk1: IC50:	>10μM
CK2: IC50:	>10μM
PHK: IC50:	>10μM
CSK: IC50:	>10μM
CDK2/CyclinA: IC50:	>10μM
PI3K: IC50:	>10μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 19.82 mL 0.1 mM_5 mg: 99.11 mL 0.1 mM_10 mg: 198.22 mL 0.5 mM_1 mg: 3.96 mL 0.5 mM_5 mg: 19.82 mL 0.5 mM_10 mg: 39.64 mL 1 mM_1 mg: 1.98 mL 1 mM_5 mg: 9.91 mL 1 mM_10 mg: 19.82 mL 5 mM_1 mg: 0.4 mL 5 mM_5 mg: 1.98 mL 5 mM_10 mg: 3.96 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.