Cyclosporine

Product Name:	Cyclosporine
CAT#:	DEPSP-2312-LGZ-3
Package:	100mg/250mg
Datasheet

Description

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

Basic Information

Application:	Calcineurin Inhibitor
CAS Number:	79217-60-0
Formula:	C62H111N11O12
Molecular Weight:	1202.61
SMILES:	CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 85 mg/mL (70.68 mM) Water: Insoluble Ethanol: 85 mg/mL (70.68 mM)
*Solubility-In vivo:*	2% DMSO+40% PEG 300+2% Tween 80+ddH2O: 2 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 8.32 mL 0.1 mM_5 mg: 41.58 mL 0.1 mM_10 mg: 83.15 mL 0.5 mM_1 mg: 1.66 mL 0.5 mM_5 mg: 8.32 mL 0.5 mM_10 mg: 16.63 mL 1 mM_1 mg: 0.83 mL 1 mM_5 mg: 4.16 mL 1 mM_10 mg: 8.32 mL 5 mM_1 mg: 0.17 mL 5 mM_5 mg: 0.83 mL 5 mM_10 mg: 1.66 mL

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