Cyt387 (Momelotinib)

Product Name:	Cyt387 (Momelotinib)
CAT#:	DEJ-2312-LGZ-5
Package:	10mg/25mg/50mg/200mg/10mM * 1mL in DMSO
Datasheet

Description

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2. As an ATP competitor, IC50 values are 11 nM and 18 nM respectively.

Basic Information

Synonyms:	CYT 11387; Cyt-387
Application:	JAK Inhibitor
CAS Number:	1056634-68-4
Formula:	C23H22N6O2
Molecular Weight:	414.5
SMILES:	C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
*Solubility-In vitro:*	In vitro (25°C): DMSO: 67 mg/mL (161.65 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	2% DMSO+40%PEG 300+ 3% Tween80 + ddH2O: 1 mg/mL

Target Info

JAK1:	11 nM
JAK2:	18 nM
JAK3:	155 nM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 24.13 mL 0.1 mM_5 mg: 120.63 mL 0.1 mM_10 mg: 241.25 mL 0.5 mM_1 mg: 4.83 mL 0.5 mM_5 mg: 24.13 mL 0.5 mM_10 mg: 48.25 mL 1 mM_1 mg: 2.41 mL 1 mM_5 mg: 12.06 mL 1 mM_10 mg: 24.13 mL 5 mM_1 mg: 0.48 mL 5 mM_5 mg: 2.41 mL 5 mM_10 mg: 4.83 mL

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