Droxinostat

Product Name:	Droxinostat
CAT#:	DEH-2312-LGZ-2
Package:	5mg/10mg/50mg/100mg/10mM * 1mL in DMSO
Datasheet

Description

Droxinostat is a selective inhibitor of HDAC3, HDAC6 and HDAC8. Its inhibitory effect on HDAC6 and HDAC8 is equivalent, with IC50 of 2.47 and 1.46 μ mol/L respectively.

Basic Information

Application:	HDAC Inhibitor
CAS Number:	99873-43-5
Formula:	C11H14ClNO3
Molecular Weight:	243.7
SMILES:	CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
*Solubility-In vitro:*	In vitro (25°C): DMSO: 47 mg/mL (192.86 mM) Water: Insoluble Ethanol: 47 mg/mL (192.86 mM)
*Solubility-In vivo:*	30% propylene glycol, 5% Tween 80, 65% D5W: 28 mg/mL

Target Info

HDAC8: IC50:	1.46μM
HDAC6: IC50:	2.47μM
HDAC3: IC50:	16.9μM
HDAC9: IC50:	>20μM
HDAC10: IC50:	>20μM
HDAC1: IC50:	>20μM
HDAC2: IC50:	>20μM
HDAC4: IC50:	>20μM
HDAC5: IC50:	>20μM
HDAC7: IC50:	>20μM

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 41.03 mL 0.1 mM_5 mg: 205.17 mL 0.1 mM_10 mg: 410.34 mL 0.5 mM_1 mg: 8.21 mL 0.5 mM_5 mg: 41.03 mL 0.5 mM_10 mg: 82.07 mL 1 mM_1 mg: 4.1 mL 1 mM_5 mg: 20.52 mL 1 mM_10 mg: 41.03 mL 5 mM_1 mg: 0.82 mL 5 mM_5 mg: 4.1 mL 5 mM_10 mg: 8.21 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.