EI1

Product Name:	EI1
CAT#:	DEHM-2312-LGZ-7
Package:	5mg/10mg/50mg
Datasheet

Description

EI1 is a small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.

Basic Information

Synonyms:	Ezh2 Inhibitor; EI-1; EI 1
Application:	EZH2 Inhibitor
CAS Number:	1418308-27-6
Formula:	C23H26N4O2
Molecular Weight:	390.48
SMILES:	CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
*Solubility-In vitro:*	DMSO: Warmed: 39 mg/mL (99.87 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

EZH2 Y641F mutant type:	13 nM (IC50)
EZH2 WT:	15 nM (EC50)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 25.61 mL 0.1 mM_5 mg: 128.05 mL 0.1 mM_10 mg: 256.1 mL 0.5 mM_1 mg: 5.12 mL 0.5 mM_5 mg: 25.61 mL 0.5 mM_10 mg: 51.22 mL 1 mM_1 mg: 2.56 mL 1 mM_5 mg: 12.8 mL 1 mM_10 mg: 25.61 mL 5 mM_1 mg: 0.51 mL 5 mM_5 mg: 2.56 mL 5 mM_10 mg: 5.12 mL

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