EPZ-5676 (Pinometostat)

Product Name:	EPZ-5676 (Pinometostat)
CAT#:	DEHM-2312-LGZ-9
Package:	5mg/10mg/25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

EPZ-5676 is a small molecule inhibitor of histone methyltransferase. It has potential anti-tumor activity.

Basic Information

Synonyms:	EPZ5676; EPZ 5676
Application:	DOT1L Inhibitor
CAS Number:	1380288-87-8
Formula:	C30H42N8O3
Molecular Weight:	562.7
SMILES:	CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 88 mg/mL (156.38 mM) Water: Insoluble Ethanol: Warmed: 81 mg/mL (143.94 mM)
*Solubility-In vivo:*	2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 4 mg/mL

Target Info

DOT1L (Cell-free assay):

80 pM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 17.77 mL 0.1 mM_5 mg: 88.86 mL 0.1 mM_10 mg: 177.71 mL 0.5 mM_1 mg: 3.55 mL 0.5 mM_5 mg: 17.77 mL 0.5 mM_10 mg: 35.54 mL 1 mM_1 mg: 1.78 mL 1 mM_5 mg: 8.89 mL 1 mM_10 mg: 17.77 mL 5 mM_1 mg: 0.36 mL 5 mM_5 mg: 1.78 mL 5 mM_10 mg: 3.55 mL

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