EPZ-6438 (Tazemetostat)

Product Name:	EPZ-6438 (Tazemetostat)
CAT#:	DEHM-2312-LGZ-8
Package:	5mg/10mg/25mg/50mg/10mM * 1mL in DMSO
Datasheet

Description

EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

Basic Information

Synonyms:	EPZ6438; EPZ 6438
Application:	EZH2 Inhibitor
CAS Number:	1403254-99-8
Formula:	C34H44N4O4
Molecular Weight:	572.74
SMILES:	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
*Solubility-In vitro:*	In vitro (25°C): DMSO: Warmed: 4 mg/mL (6.98 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	4% DMSO+30% PEG 300+5% Tween 80+ddH2O: 2.3 mg/mL

Target Info

EZH2 (Cell-free assay):	2.5 nM(Ki)
EZH2 (Cell-free assay):	2.5 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 17.46 mL 0.1 mM_5 mg: 87.3 mL 0.1 mM_10 mg: 174.6 mL 0.5 mM_1 mg: 3.49 mL 0.5 mM_5 mg: 17.46 mL 0.5 mM_10 mg: 34.92 mL 1 mM_1 mg: 1.75 mL 1 mM_5 mg: 8.73 mL 1 mM_10 mg: 17.46 mL 5 mM_1 mg: 0.35 mL 5 mM_5 mg: 1.75 mL 5 mM_10 mg: 3.49 mL

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