EPZ005687

Product Name:	EPZ005687
CAT#:	DEHM-2312-LGZ-6
Package:	5mg/10mg/25mg/50mg
Datasheet

Description

EPZ005687 is a highly effective inhibitor of EZH2 (K(i) of 24 nM).

Basic Information

Synonyms:	EPZ-005687
Application:	EZH2 Inhibitor
CAS Number:	1396772-26-1
Formula:	C32H37N5O3
Molecular Weight:	539.67
SMILES:	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC=C(C=C4)CN5CCOCC5)C6CCCC6)C
*Solubility-In vitro:*	DMSO: 2 mg/mL (3.7 mM) Water: Insoluble Ethanol: Insoluble * <1 mg/ml means slightly soluble or insoluble.

Target Info

EZH2 (Cell-free assay):

24 nM(Ki)

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 18.53 mL 0.1 mM_5 mg: 92.65 mL 0.1 mM_10 mg: 185.3 mL 0.5 mM_1 mg: 3.71 mL 0.5 mM_5 mg: 18.53 mL 0.5 mM_10 mg: 37.06 mL 1 mM_1 mg: 1.85 mL 1 mM_5 mg: 9.26 mL 1 mM_10 mg: 18.53 mL 5 mM_1 mg: 0.37 mL 5 mM_5 mg: 1.85 mL 5 mM_10 mg: 3.71 mL

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.