Fludarabine (Fludara)

Product Name:	Fludarabine (Fludara)
CAT#:	DEJ-2312-LGZ-7
Package:	10mg/50mg/100mg/(Fludara) 10mM * 1mL in DMSO
Datasheet

Description

Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used to treat hematological malignancies (cancers of blood cells such as leukemia and lymphoma). Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active on both dividing and resting cells.

Basic Information

Synonyms:	F-ara-A; NSC 118218
Application:	STAT Inhibitor
CAS Number:	21679-14-1
Formula:	C10H12FN5O4
Molecular Weight:	285.2
SMILES:	C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)F)N
*Solubility-In vitro:*	In vitro (25°C): DMSO: 52 mg/mL (182.3 mM) Water: Insoluble Ethanol: Insoluble
*Solubility-In vivo:*	30% propylene glycol, 5% Tween 80, 65% D5W: 28 mg/mL

Storage

The lyophilized form should be stored at -20°C, in a desiccated environment.
In lyophilized form, the chemical remains stable for 36 months.
In solution, it should be stored at -20°C and used within 3 months to prevent loss of potency. Aliquoting is recommended to avoid multiple freeze/thaw cycles.

Preparing Stock Solutions

0.1 mM_1 mg: 35.06 mL 0.1 mM_5 mg: 175.32 mL 0.1 mM_10 mg: 350.63 mL 0.5 mM_1 mg: 7.01 mL 0.5 mM_5 mg: 35.06 mL 0.5 mM_10 mg: 70.13 mL 1 mM_1 mg: 3.51 mL 1 mM_5 mg: 17.53 mL 1 mM_10 mg: 35.06 mL 5 mM_1 mg: 0.7 mL 5 mM_5 mg: 3.51 mL 5 mM_10 mg: 7.01 mL

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